We sincerely thank the Editor and the Reviewers for their careful evaluation of our manuscript and for their constructive comments and suggestions. We appreciate the time and effort devoted to improving the quality of our work. All comments were carefully considered, and the manuscript has been revised accordingly to address the reviewers’ concerns. The revisions have helped improve the clarity, structure, and scientific rigor of the manuscript. Specific modifications were made throughout the manuscript where appropriate, including improvements in language, clarification of methodological aspects, and refinement of the discussion to better highlight the clinical relevance and implications of our findings. We believe that these revisions have strengthened the manuscript and improved its overall quality.